The Origin of White Matter Lesions

Imaging of white matter lesions.

Magnetic resonance imaging (MRI) is very sensitive for the detection of white matter lesions (WML), which occur even in normal ageing. Intrinsic WML should be separated from physiological changes in the ageing brain, such as periventricular caps and bands, and from dilated Virchow-Robin spaces. Genuine WML are best seen with T2-weighted sequences such as long TR dual-echo spin-echo or FLAIR (fl...

The origin of white matter lesions: a further piece to the puzzle.

I ncidental areas of high signal intensity on T2-weighted MRI of older individuals termed white matter hyperintensities or white matter lesions (WML) have sparked scientific and clinical interest over the past 25 years. Extensive research has provided compelling evidence that at least more extensive forms of WMLs are a consequence of and indicative for small vessel disease, 1 and thus are assoc...

attenuation of brain white matter lesions after lacunar stroke

white matter lesions (wmls) are commonly observed in strokepatients with small vessel disease (svd) and are thought toresult from a progressive, irreversible disease process followingarteriolosclerosis. in this study, we report a case of partialdisappearance of wmls 1 year after a lacunar stroke in a69-year-old man with evidence of svd. we also discuss possiblemechanisms associated with this ob...

Significance of age-related white matter lesions.

Longitudinal Changes of White Matter Lesions

INTRODUCTION: Quantification of white matter lesion progression is of major interest in MR imaging of the human brain for the diagnosis and monitoring of several diseases like Multiple Sclerosis or Alzheimer’s disease. T1 (T1w) and T2 (T2w) weighted images may provide insufficient tissue contrast for accurate segmentation of lesions. The Fluid Attenuated Inversion Recovery (FLAIR) sequence is o...